Professor of Bioengineering, Chemistry and Biochemistry, Cellular and Molecular Medicine and Nano Engineering, and Bioengineering Department Chair, University of California at San Diego.
Title of Keynote Lecture: Engineering: the sine qua non for Systems Biology and Medicine
The advent of high throughput technologies in biology has a significant challenge and a unique set of opportunities. The challenge lies in the integrative processing of the deluge of data in the context of functional biology. The opportunities are the ability to bring strong systems engineering approaches to bear on deciphering biological mechanisms and function and most importantly the ability to develop quantitative models of biological processes. Engineering has essentially become the harbinger for next generation biology in every aspect ranging from development of innovative technologies and devices to building systems-level quantitative models.
In this talk, I will highlight,
- Aspects of new technology, especially one that is associated with next generation sequencing to obtain transcriptional parts lists and mass spectrometric methods for identifying metabolites in physiology.
- Novel statistical learning approaches that transform data from measurements in knowledge in biology.
- Insights into mechanisms in physiology that lead to normal and pathophysiology from applying engineering methods.
- Building quantitative models of biological mechanisms and phenotypes and the implications for experimental biology.
I will also outline some engineering challenges in biology for the next coming decade involving the essential paradigms of analysis, design and modeling to biological systems.
Professor Shankar Subramaniam received his Ph.D. degree in Chemistry from the Indian Institute of Technology at Kanpur. Prior to moving to UCSD, Subramaniam was a professor of biophysics, biochemistry, molecular and integrative physiology, chemical engineering and electrical and computer engineering at the University of Illinois at Urbana-Champaign (UIUC). He also was the director of the Bioinformatics and Computational Biology Program at the National Center for Supercomputing Applications (NCSA), and co-director of the W.M. Keck Center for Comparative and Functional Genomics at UIUC. He is currently the Chair of the Bioengineering Department at UCSD and holds the inaugural Joan and Irwin Jacobs Endowed Chair in Bioengineering and Systems Biology. He was the Founding Director of the UCSD Bioinformatics Graduate Program and holds the title of Distinguished Scientist at the San Diego Supercomputer Center.
As a strong advocate of systems engineering principles applied to biomedical sciences, Dr. Subramaniam’s research covers several areas of systems biology and medicine, and he is widely recognized as a leader in new areas of biomedical engineering. He is well-known as the developer of the Biology WorkBench, a Web-based analysis environment that allows biologists to search a variety of popular protein and nucleic acid sequence databases. His recent work on insulin resistance, which has revealed mechanisms associated with insulin resistance, response and non-response to thiazolidinedione drugs and identifying markers of response, have garnered significant interest in the biomedical research community. His work on macrophages and inflammation has led to novel mechanistic insights, and provided the first complete picture of mammalian lipid metabolism in response to inflammation. His work on deciphering the cellular modules involved in skeletal muscle physiology and pathophysiology is likely to have significant impact in understanding diseases such as Duchesne muscular dystrophy.
Dr. Subramaniam is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a recipient of Smithsonian Foundation and Association of Laboratory Automation Award. In 2002 he received the Genome Technology All Star Award, and in 2008, he was awarded the Faculty Excellence in Research Award at UCSD.